Key Takeaways

  • Transmission-based precautions are used IN ADDITION to standard precautions, never as a replacement
  • Contact precautions (gown and gloves) are used for MRSA, VRE, C. diff, RSV, and skin infections - remember MRS. WEE
  • Droplet precautions (surgical mask, eye protection) are for pathogens spread by large droplets >5 microns - remember SPIDERMAN
  • Airborne precautions (N95 respirator, negative pressure room) are for pathogens spread by droplet nuclei <5 microns - remember MTV
  • Patients on airborne precautions must be in an Airborne Infection Isolation Room (AIIR) with negative pressure
Last updated: January 2026

Transmission-Based Precautions

When standard precautions alone are insufficient, transmission-based precautions provide additional protection. These are used for patients with documented or suspected infections spread by specific routes.

Key Principle

Transmission-based precautions are used IN ADDITION TO standard precautions, never as a replacement. A patient on contact precautions still requires hand hygiene, PPE selection based on task, and all other standard precaution elements.


The Three Categories

CategoryTransmission RouteKey PPERoom Requirement
ContactDirect/indirect touchGown + GlovesPrivate room or cohort
DropletLarge respiratory droplets (>5 microns)Surgical mask + Eye protectionPrivate room, door may remain open
AirborneDroplet nuclei (<5 microns)N95 respiratorNegative pressure AIIR, door closed

Contact Precautions

Contact precautions prevent transmission of organisms spread through direct contact with the patient or indirect contact with contaminated surfaces.

When to Use

Use the mnemonic MRS. WEE to remember contact precaution pathogens:

LetterPathogen
MMultidrug-resistant organisms (MRSA, VRE)
RRespiratory infection (RSV)
SSkin infections (Impetigo, Scabies, Herpes Simplex, Lice)
WWound infections (draining, not contained)
EEnteric infections (C. difficile, Rotavirus, Hepatitis A)
EEye infections (Conjunctivitis/Pink eye)

Required PPE and Environment

  • Gown and gloves upon room entry
  • Private room or cohort with patient with same organism
  • Dedicated equipment (stethoscope, BP cuff) left in room
  • Hand hygiene immediately after removing PPE

Critical Points

  • Remove gown and gloves BEFORE leaving the room
  • For C. diff: use soap and water for hand hygiene (spores!)
  • Equipment that must leave the room must be disinfected

Droplet Precautions

Droplet precautions prevent transmission of organisms spread through large respiratory droplets (>5 microns) that travel short distances (approximately 3-6 feet).

When to Use

Use the mnemonic SPIDERMAN to remember droplet precaution pathogens:

LetterPathogen
SSepsis, Scarlet fever, Streptococcal pharyngitis
PPertussis (whooping cough), Pneumonia (bacterial)
IInfluenza
DDiphtheria (pharyngeal)
EEpiglottitis
RRubella (German measles)
MMumps, Meningitis (bacterial)
AAdenovirus
NRhinovirus (common cold)

Exam Tip: Rubella (German measles) is DROPLET. Rubeola (regular measles) is AIRBORNE. This distinction is frequently tested!

Required PPE and Environment

  • Surgical mask upon room entry (within 3-6 feet of patient)
  • Eye protection if splash/spray risk
  • Private room preferred; door may remain open
  • Patient wears surgical mask during transport

Key Difference from Airborne

Droplets are large and heavy - they fall to the ground within 3-6 feet. They do NOT remain suspended in the air. A regular surgical mask provides adequate protection because the particles cannot be inhaled from distance.


Airborne Precautions

Airborne precautions prevent transmission of organisms spread through droplet nuclei (<5 microns) that remain suspended in the air and can travel long distances through air currents.

When to Use

Use the mnemonic MTV to remember airborne precaution pathogens:

LetterPathogen
MMeasles (Rubeola)
TTuberculosis (TB)
VVaricella (Chickenpox) and disseminated Herpes Zoster (Shingles)

Exam Alert: COVID-19 requires special precautions including airborne precautions for aerosol-generating procedures. Follow current CDC guidelines and facility protocols.

Required PPE and Environment

  • N95 respirator (must be fit-tested) or PAPR
  • Airborne Infection Isolation Room (AIIR) with:
    • Negative pressure (air flows INTO the room)
    • Minimum 6-12 air changes per hour
    • Direct exhaust to outside or HEPA filtration
  • Door must remain CLOSED
  • Patient wears surgical mask during transport (not N95)

N95 Respirator Requirements

  • Must be fit-tested annually for each user
  • Requires seal check with each use
  • Higher level of filtration than surgical mask
  • Filters 95% of airborne particles

Room Assignment and Cohorting

Precaution TypeRoom RequirementsCohorting
ContactPrivate or cohortYes, with same organism
DropletPrivate preferredYes, with same organism
AirborneAIIR (negative pressure)No - single patient only

Combining Precautions

Some patients require multiple precaution types:

ConditionPrecautions Required
Chickenpox (Varicella)Airborne + Contact (vesicles contain virus)
Disseminated ShinglesAirborne + Contact
SARS-CoV-2Droplet + Contact (Airborne for AGPs)
Drug-resistant TBAirborne + Contact

Transport of Patients on Isolation

Precaution TypePatient Requirements
ContactCover infected areas; staff maintain precautions
DropletPatient wears surgical mask
AirbornePatient wears surgical mask (NOT N95); notify receiving department

On the NCLEX

Common testing points include:

  • Matching pathogens to correct precaution type
  • Distinguishing between Rubella (droplet) and Rubeola (airborne)
  • Understanding N95 vs surgical mask requirements
  • Knowing that airborne requires negative pressure rooms
  • Recognizing when to use soap and water vs. alcohol-based hand rub
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Hierarchy of Infection Control Precautions
Test Your Knowledge

A patient is diagnosed with active pulmonary tuberculosis (TB). Which type of isolation precautions should the nurse implement?

A
B
C
D
Test Your Knowledge

Which mnemonic helps the nurse remember pathogens requiring DROPLET precautions?

A
B
C
D
Test Your Knowledge

A nurse is assigned to care for a patient with Rubella (German measles) and a patient with Rubeola (measles). Which statement about isolation precautions is correct?

A
B
C
D