Key Takeaways

  • Contact Precautions: gown and gloves for all patient contact; used for MRSA, VRE, C. diff, scabies
  • Droplet Precautions: surgical mask within 6 feet; used for influenza, pertussis, bacterial meningitis
  • Airborne Precautions: N95 respirator, negative pressure room; used for TB, measles, varicella
  • Multiple precaution types may be combined based on the organism's transmission routes
  • Patients should be educated about the reason for isolation to reduce anxiety and promote compliance
Last updated: January 2026

Transmission-Based Precautions

When standard precautions are not sufficient to prevent transmission, additional transmission-based precautions are implemented based on how the infection spreads.

Three Types of Transmission-Based Precautions

TypeTransmission RouteRoomPPE
ContactTouch, fomitesPrivate or cohortGown and gloves
DropletLarge respiratory particlesPrivate or cohortSurgical mask (within 6 feet)
AirborneSmall airborne particlesNegative pressure, closed doorN95 respirator

Contact Precautions

Used for infections spread by direct or indirect contact.

Common Conditions:

OrganismNotes
MRSAMethicillin-resistant Staphylococcus aureus
VREVancomycin-resistant Enterococcus
C. difficileRequires soap and water for hand hygiene
ScabiesUntil 24 hours after treatment
ImpetigoUntil 24 hours after treatment
Wound infectionsLarge or draining wounds

Contact Precautions Requirements:

ElementRequirement
RoomPrivate preferred; cohort with same organism acceptable
PPEGown and gloves upon entry
EquipmentDedicated or disinfect between patients
TransportLimit; cover wounds
Hand hygieneAfter removing PPE; soap and water for C. diff

Droplet Precautions

Used for infections spread by large respiratory droplets (>5 microns).

Common Conditions:

OrganismNotes
InfluenzaSeasonal flu
PertussisWhooping cough
Bacterial meningitisN. meningitidis, H. influenzae
MumpsUntil 5 days after onset
RubellaUntil 7 days after rash onset
COVID-19May also require airborne precautions

Droplet Precautions Requirements:

ElementRequirement
RoomPrivate preferred; cohort acceptable; maintain 6-foot distance
PPESurgical mask within 6 feet of patient
TransportPatient wears surgical mask
Special ventilationNot required

Airborne Precautions

Used for infections spread by small particles that remain suspended in air.

Common Conditions:

OrganismNotes
Tuberculosis (TB)Pulmonary or laryngeal
MeaslesRubeola
VaricellaChickenpox
Disseminated zosterShingles in immunocompromised

Airborne Precautions Requirements:

ElementRequirement
RoomAirborne Infection Isolation Room (AIIR), negative pressure
PPEN95 respirator or PAPR
TransportLimit; patient wears surgical mask
DoorKeep closed
Fit testingRequired for N95 use

Airborne Infection Isolation Room (AIIR)

Features of negative pressure rooms:

  • Air flows into the room, not out
  • 6-12 air changes per hour
  • Air exhausted outdoors or through HEPA filter
  • Door must remain closed
  • Monitor pressure indicator

N95 Respirator vs. Surgical Mask

FeatureN95 RespiratorSurgical Mask
Filtration95% of small particlesDroplets only
FitTight seal, fit testing requiredLoose fit
UseAirborne precautionsDroplet precautions
ExamplesTB, measles, varicellaInfluenza, pertussis

Combining Precautions

Some conditions require multiple types:

ConditionPrecautions
Varicella (chickenpox)Airborne + Contact
Disseminated shinglesAirborne + Contact
SARS-CoV-2 (COVID-19)Droplet + Contact (some situations Airborne)
Pandemic influenzaDroplet + Contact

Patient Education and Psychosocial Support

Isolation can cause:

  • Anxiety and depression
  • Feelings of loneliness
  • Stigma and embarrassment
  • Frustration with restrictions

Nursing interventions:

  • Explain the reason for isolation clearly
  • Reassure that staff will still provide attentive care
  • Encourage family phone/video calls
  • Check on patient frequently
  • Provide diversional activities
  • Address emotional needs

Duration of Precautions

Precautions continue until:

  • Negative cultures (when applicable)
  • Symptoms resolve
  • Specific time period elapses
  • Provider discontinues order

Examples:

ConditionDuration
TBUntil 3 negative sputum smears
Pertussis5 days after antibiotic initiation
InfluenzaWhile symptomatic or per policy
VaricellaUntil all lesions crusted

On the NCLEX-PN

Expect questions about:

  • Which precautions for which conditions
  • Appropriate PPE for each precaution type
  • Room requirements for each type
  • Patient transport procedures
Test Your Knowledge

A patient is admitted with suspected pulmonary tuberculosis. Which room assignment is appropriate?

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B
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D
Test Your Knowledge

What PPE is required when entering the room of a patient on Droplet Precautions to take vital signs?

A
B
C
D
Test Your Knowledge

A patient with MRSA in a wound needs to go to radiology for an X-ray. What preparation is required?

A
B
C
D