Key Takeaways

  • Verify all medication rights: patient, medication, dose, route, time, documentation, reason, response, refusal
  • Check medication labels against MAR three times before administration
  • First action for medication error is to assess the patient for adverse effects
  • High-alert medications (insulin, anticoagulants, opioids) require additional safety checks
  • LPN/VN medication administration scope varies by state—know your state's regulations
Last updated: January 2026

Medication Administration Fundamentals

Safe medication administration is one of the most critical responsibilities of the LPN/VN. This section covers the rights of medication administration, legal considerations, and fundamental principles that ensure patient safety. This content area represents 10-16% of the NCLEX-PN exam.

The Rights of Medication Administration

The traditional "5 Rights" have expanded to include additional safety checks:

RightVerification
Right PatientCheck ID band, ask patient to state name and DOB
Right MedicationCompare label to MAR three times
Right DoseVerify calculation, check if appropriate for patient
Right RouteConfirm route matches order and formulation
Right TimeAdminister within designated window (usually ±30 min)
Right DocumentationRecord immediately after administration
Right ReasonKnow indication for the medication
Right ResponseEvaluate for expected effect and adverse reactions
Right to RefusePatient has the right to refuse; document and report

Medication Orders

Types of Orders:

Order TypeDescriptionExample
Routine/ScheduledGiven regularly at specified timesMetformin 500 mg PO BID
PRN (As Needed)Given when specific criteria are metOndansetron 4 mg IV PRN nausea
STATGiven immediately, only onceFurosemide 40 mg IV STAT
Single/One-TimeGiven once at specified timeCefazolin 1 g IV on call to OR
StandingPre-approved for specific situationsAcetaminophen 650 mg PO q4h PRN temp > 101°F

Required Components of a Valid Order:

  • Patient name
  • Date and time
  • Medication name
  • Dose
  • Route
  • Frequency
  • Prescriber signature

LPN/VN Scope of Practice

LPN/VNs can administer medications within their scope of practice, which varies by state:

Generally PermittedMay Require Additional TrainingGenerally Not Permitted
Oral medicationsIV push medicationsInvestigational drugs
Subcutaneous injectionsBlood/blood productsTitrating vasoactive drips
Intramuscular injectionsCentral line careChemotherapy (most states)
Topical medicationsPCA pump managementConscious sedation
Rectal/vaginal medsPICC dressing changesInitial IV push (some states)
Some IV fluids/medsEpidural medications

Medication Errors

Common Types of Medication Errors:

  • Wrong patient, drug, dose, route, or time
  • Omission errors (missed doses)
  • Documentation errors
  • Preparation errors
  • Monitoring errors

When a Medication Error Occurs:

  1. Assess the patient immediately for adverse effects
  2. Notify the RN/supervisor and physician promptly
  3. Document what was given and patient's response
  4. Complete incident report per facility policy (does NOT go in patient chart)
  5. Implement interventions as ordered
  6. Never hide or attempt to cover up the error

High-Alert Medications

High-alert medications have increased risk of causing significant patient harm:

CategoryExamplesSafety Measures
AnticoagulantsHeparin, warfarin, enoxaparinVerify dose, check labs (PT/INR, aPTT)
InsulinsAll formsAnother nurse must verify, never abbreviate "U"
OpioidsMorphine, fentanyl, hydromorphoneDouble-check dose, count narcotics
Concentrated ElectrolytesPotassium chloride, hypertonic salineNever give IV push, must be diluted
ChemotherapyAll antineoplastic agentsSpecialized training required
Neuromuscular BlockersSuccinylcholine, vecuroniumCauses paralysis; ventilator required

Sound-Alike/Look-Alike Medications

Be especially careful with medications that have similar names or appearances:

Confused PairPotential Consequence
Celebrex / CelexaAnti-inflammatory vs. antidepressant
Hydroxyzine / HydralazineAntihistamine vs. antihypertensive
Prednisone / PrednisoloneDifferent potencies
Humalog / HumulinRapid vs. intermediate insulin
Metformin / MetronidazoleDiabetes vs. antibiotic

Prevention Strategies:

  • Use both brand and generic names
  • Include indication on order
  • Use tall man lettering (hydrOXYzine vs. hydrALAzine)
  • Keep look-alike drugs in separate locations
  • Read labels carefully, don't rely on location or appearance
Test Your Knowledge

An LPN/VN is preparing to administer a medication. How many times should the medication label be checked against the MAR?

A
B
C
D
Test Your Knowledge

A medication error has occurred. What is the FIRST action the LPN/VN should take?

A
B
C
D
Test Your Knowledge

Which medication requires double verification by two nurses before administration?

A
B
C
D