Key Takeaways

  • The rights of medication administration: right patient, drug, dose, route, time, documentation, reason, response, and right to refuse
  • High-alert medications require extra verification steps because errors can cause serious harm
  • Look-alike/sound-alike (LASA) medications are a common source of errors and require careful verification
  • Never administer medications prepared by another nurse or unlabeled medications
  • Report medication errors immediately to ensure patient safety and prevent future errors
Last updated: January 2026

Safe Medication Administration

Medication errors are a leading cause of preventable patient harm. The LPN/LVN must follow systematic procedures to ensure every medication is administered safely.

The Rights of Medication Administration

Traditional "5 Rights" plus additional safety rights:

RightVerification
Right PatientTwo identifiers (name + DOB or MRN)
Right DrugCompare label to order, check for allergies
Right DoseCalculate if needed, verify appropriateness
Right RouteVerify route matches order and form
Right TimeWithin acceptable window of scheduled time
Right DocumentationDocument after administration
Right ReasonUnderstand why patient is receiving medication
Right ResponseMonitor for expected and adverse effects
Right to RefusePatient can decline; document and report

Before Medication Administration

Three Checks:

  1. When removing from storage
  2. When preparing/pouring medication
  3. At the patient's bedside before administration

Verify at each check:

  • Drug name matches order
  • Dose is correct
  • Expiration date is valid
  • Medication appearance is normal

High-Alert Medications

Medications that can cause significant harm if given incorrectly:

CategoryExamples
AnticoagulantsHeparin, warfarin, enoxaparin
InsulinsAll types
OpioidsMorphine, fentanyl, hydromorphone
SedativesBenzodiazepines, propofol
ChemotherapyAll cytotoxic agents
ElectrolytesPotassium chloride, sodium chloride >0.9%
Neuromuscular blockersSuccinylcholine, vecuronium

High-alert medication safety practices:

  • Independent double-check by second nurse
  • Use of tall-man lettering (e.g., DOPamine vs. DOBUTamine)
  • Limited access storage
  • Standardized concentrations
  • Smart pump programming

Look-Alike/Sound-Alike (LASA) Medications

Common LASA pairs that cause confusion:

DrugConfused With
MetforminMetronidazole
HydroxyzineHydralazine
PrednisonePrednisolone
ClonidineKlonopin
TramadolTrazodone
CelebrexCelexa

Prevention strategies:

  • Read labels carefully, do not assume
  • Use both brand and generic names
  • Verify indication for the medication
  • Question if something doesn't make sense

Allergies and Adverse Reactions

Always verify allergies before administration:

  • Check allergy band
  • Verify in medical record
  • Ask patient directly

Types of reactions:

ReactionDescriptionAction
Side effectKnown, expected effectMonitor, may continue
Adverse reactionUnintended, harmful effectReport, may discontinue
Allergic reactionImmune responseStop medication, treat symptoms
AnaphylaxisSevere, life-threateningEmergency response, epinephrine

Safe Medication Practices

DoDon't
Verify orders are complete and legibleAdminister unclear orders
Calculate doses independentlyAssume calculations are correct
Check compatibility before mixingMix medications without verification
Label all syringesLeave syringes unlabeled
Administer medications you preparedGive medications prepared by others
Question orders that seem inappropriateAssume the prescriber is always right

When to Question an Order

Contact prescriber or pharmacist if:

  • Order is unclear or incomplete
  • Dose seems unusually high or low
  • Route seems inappropriate
  • Patient has documented allergy
  • Drug interaction is suspected
  • Order doesn't match diagnosis

Document:

  • That you questioned the order
  • Response received
  • Action taken

Medication Errors

If an error occurs:

  1. Assess the patient immediately
  2. Notify the provider and supervising RN
  3. Monitor for adverse effects
  4. Document accurately in the medical record
  5. Complete an incident report (per facility policy)
  6. Do not document "incident report filed" in the chart

Types of errors:

Error TypeExample
OmissionMissed dose
Wrong dose10 mg instead of 1 mg
Wrong drugSimilar name confusion
Wrong routeIV instead of IM
Wrong timeGiven 4 hours late
Wrong patientPatient misidentified

Controlled Substance Safety

Requirements for controlled substances:

  • Count at shift change
  • Dual signature for waste
  • Secure storage
  • Accurate documentation
  • Report discrepancies immediately

Signs of diversion:

  • Frequent "wasted" medications
  • Patients reporting inadequate pain relief
  • Unusual patterns of medication administration
  • Tampering with medication packaging

On the NCLEX-PN

Expect questions about:

  • The rights of medication administration
  • High-alert medication precautions
  • Appropriate response to medication errors
  • When to question medication orders
Test Your Knowledge

Before administering insulin, what additional safety step is required?

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D
Test Your Knowledge

An LPN prepares to give a medication and realizes it looks different from what the patient usually receives. What should the LPN do?

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B
C
D
Test Your Knowledge

An LPN accidentally gives the wrong dose of a medication. The patient shows no adverse effects. What should the LPN do FIRST?

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B
C
D